on track:
What you
can do

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During treatment with VENCLEXTA-based therapy

  • Take VENCLEXTA exactly as your healthcare provider tells you to take it
  • When you first take VENCLEXTA:
    • You may need to take VENCLEXTA at a hospital or clinic to be monitored for TLS
    • Your healthcare provider will start VENCLEXTA at a low dose and slowly increase it daily up to the full dose. Follow your healthcare provider’s instructions carefully while increasing to the full dose
  • Drink plenty of water during treatment with VENCLEXTA to help reduce your risk of getting TLS
    • Drink 6 to 8 glasses (about 56 ounces total) of water each day, starting 2 days before your first dose, on the day of your first dose of VENCLEXTA, and each time your dose is increased
  • Your healthcare provider may delay, decrease your dose, or stop treatment if side effects occur
    • When restarting VENCLEXTA after stopping for 1 week or longer, your healthcare provider may check again for risk of TLS and change your dose
  • Take VENCLEXTA 1 time a day with a meal and water at about the same time each day
  • Swallow VENCLEXTA tablets whole
  • Keep VENCLEXTA in original packaging to protect from moisture
  • If you miss a dose of VENCLEXTA and it has been less than 8 hours, take your dose as soon as possible
    • If you miss a dose of VENCLEXTA and it has been more than 8 hours, skip the missed dose and take the next dose at your usual time
  • Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. VENCLEXTA and other medicines may affect each other, causing serious side effects
  • Don’t change your dose of VENCLEXTA or stop taking VENCLEXTA unless your healthcare provider tells you to
  • Don’t crush, chew, or break the tablets
  • Don’t transfer tablets to a different container
  • Don’t take an extra dose if you vomit after taking VENCLEXTA. Take the next dose at your scheduled time the next day
  • Don’t drink grapefruit juice or eat grapefruit, Seville oranges (often used in marmalades), or starfruit while you are taking VENCLEXTA. These products may increase the amount of VENCLEXTA in your blood
  • Don't start new medicines during treatment with VENCLEXTA without first talking with your healthcare provider

VENCLEXTA can cause serious side effects, including tumor lysis syndrome (TLS)

TLS is caused by the fast breakdown of cancer cells. It can cause kidney failure, the need for dialysis treatment, and may lead to death. Your healthcare provider will do tests for TLS, so keeping appointments for those tests is important. To help reduce TLS risk, you will receive other medicines before starting and during treatment with VENCLEXTA. You may also need to receive intravenous fluids into your vein. If you have any symptoms of TLS during treatment with VENCLEXTA, including fever, chills, nausea, vomiting, confusion, shortness of breath, seizures, irregular heartbeat, dark or cloudy urine, unusual tiredness, or muscle or joint pain, tell your healthcare provider right away.


It is important to understand your pill schedule

Get the full dosing and ramp-up schedule for VENCLEXTA.


Keep track of
when you take
your medication

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Learn more about VENCLEXTA treatment