Acute Myeloid Leukemia

Possible side effects of VENCLEXTA regimens

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Side effects to watch for

Serious side effects

Each person responds differently to VENCLEXTA in combination with azacitidine, or decitabine, or low-dose cytarabine. Side effects are a real possibility and can be very serious. Serious side effects include:

VENCLEXTA can cause serious side effects, including tumor lysis syndrome (TLS):

TLS is caused by the fast breakdown of cancer cells. It can cause kidney failure, the need for dialysis treatment, and may lead to death. Your healthcare provider will do tests for TLS, so keeping appointments for those tests is important. To help reduce TLS risk, you will receive other medicines before starting and during treatment with VENCLEXTA. You may also need to receive intravenous fluids into your vein.

Tell your healthcare provider right away if you have any symptoms of TLS during treatment with VENCLEXTA, including:

  • Fever
  • Chills
  • Nausea
  • Vomiting
  • Confusion
  • Shortness of breath
  • Seizures
  • Irregular heartbeat
  • Dark or cloudy urine
  • Unusual tiredness
  • Muscle or joint pain
  • Fever
  • Chills
  • Nausea
  • Vomiting
  • Confusion
  • Shortness of breath
  • Seizures
  • Irregular heartbeat
  • Dark or cloudy urine
  • Unusual tiredness
  • Muscle or joint pain

Low white blood cell counts (neutropenia)

Low white blood cell counts are common with VENCLEXTA but can also be severe. Your healthcare provider will do blood tests to check your blood counts during treatment with VENCLEXTA and possibly pause dosing.

Infections

Death and serious infections such as pneumonia and blood infection (sepsis) have happened during treatment with VENCLEXTA. Your healthcare provider will closely monitor and treat you right away if you have a fever or any signs of infection during treatment with VENCLEXTA. Tell your healthcare provider if you have a fever or any signs of an infection during your treatment with VENCLEXTA and possibly pause dosing.

Some people may experience other side effects.

VENCLEXTA Patient Brochure

VENCLEXTA Patient Brochure

For more information about these side effects, see the VENCLEXTA Patient Brochure.

Common side effects

The most common side effects of VENCLEXTA in combination with azacitidine, or decitabine, or low-dose cytarabine include:

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Blood-related symptoms

  • Low platelet count (cells in blood that help it to stop bleeding after a cut)
  • Low white blood cell count
  • Fever with low white blood cell count
  • Low red blood cell count
  • Low blood pressure
  • Bleeding
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Respiratory symptoms

  • Cough
  • Shortness of breath
  • Sore throat
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Digestive and stomach symptoms

  • Nausea
  • Diarrhea
  • Vomiting
  • Stomach (abdominal) pain
  • Constipation
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General symptoms

  • Tiredness
  • Infection in blood
  • Infection in lungs
  • Muscle and joint pain
  • Swelling of arms, legs, hands, or feet
  • Fever
  • Rash
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Neurological symptoms

  • Dizziness

Your healthcare provider may delay or decrease your dose or stop treatment if you have side effects. Don’t stop or change your dose unless directed by your healthcare provider. VENCLEXTA may cause fertility problems in men. This may affect your ability to father a child. Talk to your healthcare provider if you have concerns about fertility. These are not all the possible side effects of VENCLEXTA. Call your healthcare provider for medical advice about side effects.

You may report side effects to the FDA at fda.gov/medwatch or call the number below.

Helpful tips while on treatment

It's important to take care of yourself while on treatment. The therapies below can help you practice a healthy lifestyle:

Dumbbell icon Exercise
Meditation icon Meditation
Acupuncture icon Acupuncture
Candle and massage stones icon Therapeutic massage
Yoga mat and water bottle icon Yoga

 

Check with your healthcare provider before practicing any of the above therapies.

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PATIENT BROCHURE

Get information about treatment with VENCLEXTA

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