Previously Untreated CLL/SLL
VENCLEXTA IS DESIGNED TO BE DIFFERENT
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A treatment you can complete
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Fixed treatment periodVENCLEXTA is designed to be completed in a set amount of time (12 months in combination with GAZYVA® [obinutuzumab] for previously untreated CLL/SSL and about 24 months in combination with rituximab for previously treated CLL/SLL), unlike some other oral therapies that you take until your cancer progresses. |
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Fixed amount of drug exposureBecause the VENCLEXTA regimens are taken for a fixed period of time, there is no additional VENCLEXTA exposure after completing treatment. |
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Fixed costBecause treatment with VENCLEXTA is completed in a set amount of time, your out-of-pocket costs for the VENCLEXTA regimens are limited to 12 months for previously untreated patients or about 24 months for previously treated patients.* *Coverage may vary by health plan. You may still incur out-of-pocket costs for other treatments or tests as directed by your healthcare provider. |
A treatment that is chemo-free
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VENCLEXTA regimens are oral-based, chemo-free treatments for CLL/SLL that you take for 12 months if previously untreated or about 24 months if previously treated. Your healthcare provider will often prescribe VENCLEXTA with an intravenously administered antibody therapy, such as GAZYVA if you are previously untreated or rituximab if you are previously treated, to help you fight CLL or SLL. Your healthcare provider may prescribe VENCLEXTA alone in previously treated CLL/SLL, which is taken until your healthcare provider tells you to stop. |
Always take VENCLEXTA as directed by your healthcare provider.
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Established efficacy and safety
Learn more about results from the VENCLEXTA clinical trial.
VENCLEXTA is designed to be completed in a set amount of time (12 months for previously treated CLL/SLL when combined with GAZYVA or about 24 months for previously treated CLL/SLL when combined with rituximab), unlike some other oral therapies that you take until your disease progresses.
PATIENT BROCHURE
Get more information about treatment with VENCLEXTA
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Learn more about how VENCLEXTA can help
Important Safety Information
What is the most important information I should know about VENCLEXTA?
VENCLEXTA can cause serious side effects, including:
Tumor lysis syndrome (TLS). TLS is caused by the fast breakdown of cancer cells. TLS can cause kidney failure, the need for dialysis treatment, and may lead to death. Your healthcare provider will do tests to check your risk of getting TLS before you start taking VENCLEXTA. You will receive other medicines before starting and during treatment with VENCLEXTA to help reduce your risk of TLS. You may also need to receive intravenous (IV) fluids into your vein. Your healthcare provider will do blood tests to check for TLS when you first start treatment and during treatment with VENCLEXTA. It is important to keep your appointments for blood tests. Tell your healthcare provider right away if you have any symptoms of TLS during treatment with VENCLEXTA, including fever, chills, nausea, vomiting, confusion, shortness of breath, seizures, irregular heartbeat, dark or cloudy urine, unusual tiredness, or muscle or joint pain.
Drink plenty of water during treatment with VENCLEXTA to help reduce your risk of getting TLS. Drink 6 to 8 glasses (about 56 ounces total) of water each day, starting 2 days before your first dose, on the day of your first dose of VENCLEXTA, and each time your dose is increased.
Your healthcare provider may delay, decrease your dose, or stop treatment with VENCLEXTA if you have side effects.
Who should not take VENCLEXTA?
Certain medicines must not be taken when you first start taking VENCLEXTA and while your dose is being slowly increased because of the risk of increased TLS.
- Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. VENCLEXTA and other medicines may affect each other causing serious side effects.
- Do not start new medicines during treatment with VENCLEXTA without first talking with your healthcare provider.
Before taking VENCLEXTA, tell your healthcare provider about all of your medical conditions, including if you:
- have kidney or liver problems.
- have problems with your body salts or electrolytes, such as potassium, phosphorus, or calcium.
- have a history of high uric acid levels in your blood or gout.
- are scheduled to receive a vaccine. You should not receive a “live vaccine” before, during, or after treatment with VENCLEXTA, until your healthcare provider tells you it is okay. If you are not sure about the type of immunization or vaccine, ask your healthcare provider. These vaccines may not be safe or may not work as well during treatment with VENCLEXTA.
- are pregnant or plan to become pregnant. VENCLEXTA may harm your unborn baby. If you are able to become pregnant, your healthcare provider should do a pregnancy test before you start treatment with VENCLEXTA, and you should use effective birth control during treatment and for at least 30 days after the last dose of VENCLEXTA. If you become pregnant or think you are pregnant, tell your healthcare provider right away.
- are breastfeeding or plan to breastfeed. It is not known if VENCLEXTA passes into your breast milk. Do not breastfeed during treatment with VENCLEXTA.
What should I avoid while taking VENCLEXTA?
You should not drink grapefruit juice or eat grapefruit, Seville oranges (often used in marmalades), or starfruit while you are taking VENCLEXTA. These products may increase the amount of VENCLEXTA in your blood.
What are the possible side effects of VENCLEXTA?
VENCLEXTA can cause serious side effects, including:
- Low white blood cell counts (neutropenia). Low white blood cell counts are common with VENCLEXTA, but can also be severe. Your healthcare provider will do blood tests to check your blood counts during treatment with VENCLEXTA.
- Infections. Death and serious infections such as pneumonia and blood infection (sepsis) have happened during treatment with VENCLEXTA. Your healthcare provider will closely monitor and treat you right away if you have a fever or any signs of infection during treatment with VENCLEXTA.
Tell your healthcare provider right away if you have a fever or any signs of an infection during treatment with VENCLEXTA.
The most common side effects of VENCLEXTA when used in combination with obinutuzumab or rituximab or alone in people with CLL or SLL include low white blood cell counts; low platelet counts; low red blood cell counts; diarrhea; nausea; upper respiratory tract infection; cough; muscle and joint pain; tiredness; and swelling of your arms, legs, hands, and feet.
VENCLEXTA may cause fertility problems in males. This may affect your ability to father a child. Talk to your healthcare provider if you have concerns about fertility.
These are not all the possible side effects of VENCLEXTA. For more information, ask your healthcare provider or pharmacist.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit
or call 1-800-FDA-1088.
US-VENC-190384
