TLS is a serious side effect

VENCLEXTA can cause the fast breakdown of cancer cells. When many cancer cells are quickly broken down, there is a danger of tumor lysis syndrome (TLS). TLS can cause kidney failure, the need for dialysis treatment, and may lead to death.

What are the symptoms of TLS?

Tell your healthcare provider right away if you have any of the following symptoms of TLS during treatment with VENCLEXTA® + rituximab:

What can I do to help prevent TLS? 

The risk of TLS can vary for different people. To determine your risk of getting TLS, your healthcare provider will do tests before you start VENCLEXTA.

Steps to monitor and help prevent TLS