What is TLS?

TLS (tumor lysis syndrome) is a serious side effect caused by the fast breakdown of cancer cells. TLS can cause kidney failure, the need for dialysis treatment, and may lead to death. So tell your doctor right away if you experience symptoms associated with TLS, including:

  • Fever
  • Chills
  • Nausea
  • Vomiting
  • Confusion
  • Shortness of breath
  • Seizures
  • Irregular heartbeat
  • Dark or cloudy urine
  • Unusual tiredness
  • Muscle or joint pain

In clinical trials, 1% of people (3 of 212) treated with VENCLEXTA + GAZYVA® (obinutuzumab) and 3% of people (6 of 194) treated with VENCLEXTA + rituximab had TLS. All cases were resolved and none led to withdrawal from the study.

It’s important to follow your healthcare provider’s instructions and to follow the prevention tips below

Tips for helping prevent TLS

The risk of TLS can vary for different people. To determine your risk of getting TLS, your healthcare provider will do blood tests before you start VENCLEXTA.