Previously Treated CLL/SLL

DOSING SCHEDULE

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Treatment with VENCLEXTA + rituximab is designed to be completed in ~24 months

VENCLEXTA is a pill that you take once a day. Your healthcare provider may prescribe VENCLEXTA with rituximab, an antibody infusion therapy.

You will start taking VENCLEXTA at a low dose and gradually build up to a higher dose—this is known as a "ramp-up" period. This dose ramp-up is designed to gradually destroy your cancer cells and may help reduce your risk of tumor lysis syndrome (TLS).

Your healthcare provider may tell you to take VENCLEXTA differently than described here. Take VENCLEXTA exactly as prescribed by your healthcare provider. Do not start taking VENCLEXTA until you have reviewed the specific instructions with your healthcare provider. You may be directed to take your first dose and any increase in dose in your healthcare provider’s office or at the hospital.

How should VENCLEXTA be taken?

  • Do not change your dose of VENCLEXTA or stop taking VENCLEXTA unless your healthcare provider tells you to
  • When you first take VENCLEXTA, you may need to take VENCLEXTA at a hospital or clinic to be monitored for TLS
  • Take VENCLEXTA 1 time a day with a meal and water at about the same time each day
  • Swallow VENCLEXTA tablets whole. Do not chew, crush, or break the tablets
  • If you miss a dose of VENCLEXTA and it has been less than 8 hours, take your dose as soon as possible. If you miss a dose of VENCLEXTA and it has been more than 8 hours, skip the missed dose and take the next dose at your usual time
  • If you vomit after taking VENCLEXTA, do not take an extra dose. Take the next dose at your usual time the next day

What is the most important information to know about VENCLEXTA?

  • Drink plenty of water during treatment with VENCLEXTA to help reduce your risk of getting TLS
  • Drink 6 to 8 glasses (about 56 ounces total) of water each day, starting 2 days before your first dose, on the day of your first dose of VENCLEXTA, and each time your dose is increased
  • Your healthcare provider may delay, decrease your dose, or stop treatment with VENCLEXTA if you have side effects

See important information about getting started with VENCLEXTA.

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Download the VENCLEXTA calendar

Weeks 1-5

You will start taking VENCLEXTA at a low dose and gradually build up to a higher dose—this is known as a “ramp-up” period. This dose ramp-up is designed to gradually destroy your cancer cells and may help reduce your risk of tumor lysis syndrome (TLS).

Chart showing dosing in weeks 1 through 5

Week 6 to Month 6

After the VENCLEXTA 5-week ramp-up period, you will begin receiving rituximab on the first day of each month. Continue taking VENCLEXTA 400 mg once daily or as prescribed.

Chart showing dosing in week 6 through month 6

Months 7–24

You will continue to take VENCLEXTA once daily until the end of the ~24-month treatment period.

Chart showing dosing in months 7 through 24

 Treatment is designed to be completed in about 24 months

If your doctor prescribed VENCLEXTA alone:

You will start taking VENCLEXTA at a low dose and gradually build up to a higher dose—this is known as a "ramp-up" period.

You will continue taking VENCLEXTA at the full recommended daily dose of 400 mg until your healthcare provider tells you to stop or changes your dose.

VENCLEXTA should be taken at the recommended daily dose as prescribed until your healthcare provider tells you to stop taking VENCLEXTA or changes your dose

VENCLEXTA CALENDAR

Keep your dosing schedule handy

It is not known if VENCLEXTA is safe and effective in children.

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Learn more about VENCLEXTA treatment