VENCLEXTA ramp-up dosing

Your doctor will start your VENCLEXTA treatment at a low daily dose of 20 mg and gradually increase, or ramp up, the dose over 5 weeks to the full recommended daily dose. By ramping up with VENCLEXTA, cells are destroyed more slowly over time and may help reduce your risk of tumor lysis syndrome (TLS).

Do not start taking VENCLEXTA until you have reviewed specific instructions with your doctor.

You may be directed to take your first dose and any increase in dose in your doctor’s office or hospital. Your doctor may delay, decrease your dose, or stop treatment if you have side effects.

VENCLEXTA dosing schedule image

Before taking VENCLEXTA, tell your doctor about all of your medical conditions, including if you:

  • have kidney or liver problems
  • have problems with your body salts or electrolytes, such as potassium, phosphorus, or calcium
  • have a history of high uric acid levels in your blood or gout
  • are scheduled to receive a vaccine. You should not receive a “live vaccine” before, during, or after treatment with VENCLEXTA, until your doctor tells you it is okay. If you are not sure about the type of immunization or vaccine, ask your doctor. These vaccines may not be safe or may not work as well during treatment with VENCLEXTA
  • are pregnant or plan to become pregnant. VENCLEXTA may harm your unborn baby. If you are able to become pregnant, your doctor should do a pregnancy test before you start treatment with VENCLEXTA. Females who are able to become pregnant should use effective birth control during treatment and for 30 days after the last dose of VENCLEXTA. If you become pregnant or think you are pregnant, tell your doctor right away
  • are breastfeeding or plan to breastfeed. It is not known if VENCLEXTA passes into your breast milk. Do not breastfeed during treatment with VENCLEXTA.

Certain medicines must not be taken when you first start taking VENCLEXTA and while your dose is being slowly increased.

  • Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. VENCLEXTA and other medicines may affect each other causing serious side effects
  • Do not start new medicines during treatment with VENCLEXTA without first talking with your doctor

For more information about what you should tell your doctor before using VENCLEXTA, please see the Medication Guide.