VENCLEXTA side effects can be managed with your healthcare provider after discussing all your medical conditions with him or her.

VENCLEXTA can cause serious side effects

  • Tumor lysis syndrome (TLS): TLS is a serious side effect caused by the fast breakdown of cancer cells. In a clinical trial, 3% of people (6 of 194) treated with VENCLEXTA + rituximab had TLS. It resolved and did not lead to withdrawal from the study. Go to TLS prevention tips to learn more
  • Low white blood cell count: Also called neutropenia, low white blood cell count is common with VENCLEXTA but can also be severe. Your healthcare provider will do blood tests to check your blood counts during treatment with VENCLEXTA
  • Infections: Death and serious infections such as pneumonia and blood infection (sepsis) have happened during treatment with VENCLEXTA. Your healthcare provider will closely monitor and treat you right away if you have fever or any sign of infection during treatment with VENCLEXTA. Tell your healthcare provider right away if you have a fever or any signs of an infection during treatment with VENCLEXTA

Common side effects that occurred with VENCLEXTA when used in combination with GAZYVA® (obinutuzumab) or rituximab or alone:

  • Low white blood cell counts
  • Low platelet counts
  • Low red blood cell counts
  • Diarrhea
  • Nausea
  • Upper respiratory tract infection
  • Cough
  • Muscle and joint pain
  • Tiredness
  • Swelling of your arms, legs, hands, and feet