TLS is a serious side effect, caused by the fast breakdown of cancer cells. TLS can cause kidney failure, the need for dialysis treatment, and may lead to death.

Tell your doctor right away if you have any of the following symptoms of TLS during treatment with VENCLEXTA™:

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What can I do to help prevent TLS?

The risk of TLS can vary for different people. To determine your risk of getting TLS, your doctor will need to do tests before you start VENCLEXTA.

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  • Drink plenty of water when taking VENCLEXTA to help reduce your risk of getting TLS. Drink 6-8 glasses (approximately 56 ounces total) of water each day, starting 2 days before your first dose, on the day of your first dose, and each time your dose is increased
  • You will receive other medicines before starting and during treatment with VENCLEXTA to help reduce your risk of TLS. You may also need to receive intravenous (IV) fluids
  • Your doctor will do blood tests in your first 5 weeks of treatment to check for TLS during treatment with VENCLEXTA. It is important to keep your appointments for blood tests
  • Your doctor may delay, decrease your dose, or stop treatment with VENCLEXTA if you have side effects